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We synthesize and characterize As(Cys)3, Sb(Cys)3, and Bi(Cys)3, describe their crystal structures, analyze structural trends across Pn(SR)3compounds, and compare their features to the structures of proteins with these centers bound to Cys3motifs.more » « lessFree, publicly-accessible full text available December 3, 2025
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Hollow, Sophia E.; Johnstone, Timothy C. (, Chemical Communications)Na 2 B 12 I 12 has many of the properties desired by an X-ray contrast agent but is lethal at the concentrations needed for medical imaging. We demonstrate here that PBS solutions with >50 mM Na 2 B 12 I 12 induce hemolysis, consistent with the previously reported superchaotropic nature of the anion. The presence of <1 equiv. of 2-hydroxypropyl-γ-cyclodextrin prevents hemolysis and suggests a strategy for exploiting B 12 I 12 2− as an X-ray contrast agent.more » « less
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